Physiology I

Gmelinstraße 5
D-72076 Tübingen
phone: +49 (0)7071 29-72194
telefax: +49 (0)7071 29-3073

Head of Department

interim chairman : Prof. Dr. Olga Garaschuk

csm_garaschuk_olga_c90dbac830.jpg contact : Physiology II

senior professor : Prof. Dr. med. Florian Lang


phone: +49 (0)7071 29-72194
fax: +49 (0)7071 29-5618

phone: +49 (0)7071 29-72194

Research Interests

Research in the department focusses on properties and regulation of ion channels and transporters, cell volume regulation, suicidal cell death and host pathogen interaction. Scientist at the department come from more than a dozen countries and enjoy the free exchange of ideas, the joint efforts and the opportunity to pursue their goals with international cooperations.

Cell Size Matters

Erythrocyte death signaling

Serum-and Glucocorticoid inducible kinase isoforms

Studying Human Channels And Carriers In Frog Oocytes

The Role Of The Victim During Infection

The Suicide Machinery

Selected Publications

Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1.
Kim MJ, Chae JS, Kim KJ, Hwang SG, Yoon KW, Kim EK, Yun HJ, Cho JH, Kim J, Kim BW, Kim HC, Kang SS, Lang F, Cho SG, Choi EJ
EMBO J26p3075-85(2007 Jul 11)
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.
Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E, Lang F
Nat Med13p164-70(2007 Feb)
Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.
Zhang W, Xia X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone BC
J Clin Invest117p773-83(2007 Mar)
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V
Physiol Rev86p1151-78(2006 Oct)
KCNQ1-dependent transport in renal and gastrointestinal epithelia.
Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F
Proc Natl Acad Sci U S A102p17864-9(2005 Dec 6)
Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation.
Huber SM, Uhlemann AC, Gamper NL, Duranton C, Kremsner PG, Lang F
EMBO J21p22-30(2002 Jan 15)
Impaired renal Na(+) retention in the sgk1-knockout mouse.
Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K, Jansen M, Schlünz M, Klingel K, Loffing J, Kauselmann G, Bösl MR, Lang F, Kuhl D
J Clin Invest110p1263-8(2002 Nov)
CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa.
Grassmé H, Kirschnek S, Riethmueller J, Riehle A, von Kürthy G, Lang F, Weller M, Gulbins E
Science290p527-30(2000 Oct 20)
Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.
Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen I, Steuer S, Waldegger S, Sauter M, Paulmichl M, Gerke V, Risler T, Gamba G, Capasso G, Kandolf R, Hebert SC, Massry SG, Broër S
Proc Natl Acad Sci U S A97p8157-62(2000 Jul 5)
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus.
Grifa A, Wagner CA, D'Ambrosio L, Melchionda S, Bernardi F, Lopez-Bigas N, Rabionet R, Arbones M, Monica MD, Estivill X, Zelante L, Lang F, Gasparini P
Nat Genet23p16-8(1999 Sep)
Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids.
Lepple-Wienhues A, Belka C, Laun T, Jekle A, Walter B, Wieland U, Welz M, Heil L, Kun J, Busch G, Weller M, Bamberg M, Gulbins E, Lang F
Proc Natl Acad Sci U S A96p13795-800(1999 Nov 23)
Functional significance of cell volume regulatory mechanisms.
Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E, Häussinger D
Physiol Rev78p247-306(1998 Jan)
Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes.
Szabò I, Lepple-Wienhues A, Kaba KN, Zoratti M, Gulbins E, Lang F
Proc Natl Acad Sci U S A95p6169-74(1998 May 26)
Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells.
Wagner CA, Giebisch G, Lang F, Geibel JP
Proc Natl Acad Sci U S A95p9665-8(1998 Aug 4)
Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells.
Grassmé H, Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang F, Meyer TF
Cell91p605-15(1997 Nov 28)
Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases.
Gulbins E, Szabo I, Baltzer K, Lang F
Proc Natl Acad Sci U S A94p7661-6(1997 Jul 8)
L-selectin activates the Ras pathway via the tyrosine kinase p56lck.
Brenner B, Gulbins E, Schlottmann K, Koppenhoefer U, Busch GL, Walzog B, Steinhausen M, Coggeshall KM, Linderkamp O, Lang F
Proc Natl Acad Sci U S A93p15376-81(1996 Dec 24)
Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.
Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Broer S, Biber J, Murer H, Lang F
Proc Natl Acad Sci U S A93p5347-51(1996 May 28)
Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter.
van Kuijck MA, van Aubel RA, Busch AE, Lang F, Russel FG, Bindels RJ, van Os CH, Deen PM
Proc Natl Acad Sci U S A93p5401-6(1996 May 28)
Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway.
Gulbins E, Coggeshall KM, Brenner B, Schlottmann K, Linderkamp O, Lang F
J Biol Chem271p26389-94(1996 Oct 18)
Electrophysiological analysis of Na+/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes.
Busch A, Waldegger S, Herzer T, Biber J, Markovich D, Hayes G, Murer H, Lang F
Proc Natl Acad Sci U S A91p8205-8(1994 Aug 16)
Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes.
Busch GL, Schreiber R, Dartsch PC, Völkl H, Vom Dahl S, Häussinger D, Lang F
Proc Natl Acad Sci U S A91p9165-9(1994 Sep 13)
Cellular hydration state: an important determinant of protein catabolism in health and disease.
Häussinger D, Roth E, Lang F, Gerok W
Lancet341p1330-2(1993 May 22)
New clues to the pathophysiology of hepatorenal failure.
Lang F, Gerok W, Häussinger D
Clin Investig71p93-7(1993 Feb)

Scientific Grants

IZKF Verbundprojektantrag 1466-0-0

Der PI3K/Akt-Signalweg in Pathogenese und Therapie von soliden Tumoren
Else Übelmesser Stiftung

Rolle des programmierten Erythrozytenzelltods bei der Zytostatika-induzierten Anämie

European Genomics Initiative on Disorders of plasma membrane Amino acid Transporters
IZKF Promotionskolleg Molekulare Medizin
DFG-Hu 781/4-3

Schwerpunktprogramm: Intrazelluläre Lebensformen: (Lang/Huber) Ion channels and suicidal death of Plasmodium falciparum-infected erythrocytes
DFG-La 315/14-1

Kinasen in der Regulation von Transportprozessen der Zellmembran
DFG-La 315/13-2

Mechanismen und Regulation erythrocytärer Apoptose
DFG-La 315/11-2

Schwerpunktprogramm: Intrazelluläre Lebensformen: (Huber/Lang) Cell volume regulated ion channels in Plasmodium falciparum-infected erythrocytes
SFB/Transregio 19

Teilprojekt B5: Inflammatorische Kardiomyopathie - Molekulare Pathogenese und Therapie
DFG-Graduiertenkolleg GRK 1302/1

Der PI3K Signalweg bei Tumorwachstum und Diabetes
DFG-436 RUS 121/18/06 (R)

Pathophysiology of mental diseases

Official Positions

1992-today Head of the first Department of Physiology

1994-2002 Secretary and treasurer of the German Society of Nephrology

2000-2001 President of the German Physiological Society

2003-2004 Student Dean for preclinical studies


Associate editor of NEPHRON

Executive editor of PFLÜGERS ARCHIV

Member of the editorial board of the AMERICAN JOURNAL of PHYSIOLOGY/RENAL,



Last modified:: 15.04.2016 10:07